Interventional Radiology (IR), thanks to the development of technological and knowledge skills, has achieved a first-line role in the treatment of bone lesions. In particular, a large range of benign and malignant lesions can be treated: not only the well-known ablations of osteoid osteoma and bone metastasis can be performed, but also the ablation of lesions that are painful but classified as benign (Periosteal Chondroma, Periosteal Desmoid, …). The indication for ablation is the pain relief, avoiding surgery (clearly more invasive) otherwise required to treat these lesions; however, there is an increasing interest in the IR for the possibility of a curative role especially in the case of an oligometastatic disease. All the techniques of the IR at date available will be described because, the choice of the most appropriate technique must be done in relation to the position and the characteristics of the lesions: for example, MRgFUS is the most suitable technique for lesions on the bone surface, instead the Cryoablation is a very handy and effective technique for large lesions with irregular margins and morphologies. RFA, MWA, and TAE will be also discussed. The main advantages of this technique of IR are the low grade of invasiveness and the low incidence of complications that occur compared with the very high rate of effectiveness, also in patients with poor health conditions.