To assess the diagnostic performance of WB-DWIBS compared to FDG-PET-CT in an assessment of breast cancer patients.
METHOD AND MATERIALS:
50 patients with pathologically proven breast cancer underwent both F-18-FDG PET-CT and WB-MRI/DWIBS. The sequences acquired are whole-body DWI, coronal T1, and coronal STIR. FDG-PET/CT was performed on an integrated PET-CT system. Whole body F18 FDG-PET CT was performed using a standard technique. Both F-18-FDG PET-CT and WB-MRI/DWIBS were independently interpreted using visual qualitative and quantitative analysis in the term of SUV max and ADC value respectively. Using pathological data and / or combined clinical / radiological follow-up as a reference standard, Sensitivity, specificity, PPV, NPV and overall accuracy were estimated for both techniques.
F-18 FDG PET-CT demonstrated slightly higher specificity indices than MR-DWIBS while the MR-DWIBS displays higher sensitivity indices than FDG PET CT in particular in loco-regional assessment. In addition, high sensitivity indices of DWIBS were depicted in an assessment of nodal and bone marrow lesions with fair specificity indices. A high degree of the agreement also existed between DWIBS and PET CT with the little better accuracy of FDG PET CT more appreciated in the pulmonary lesions assessment.
WB-MRI/DWIBS is a promising tool in the evaluation of cancer patients in particular breast cancer.
An easy technique for detection and assessment of metastasis with no radiation exposure.