Assoc.Prof.Dr. Oliver Szasz is one of the technical developers of endothermic method. He is the CEO of the Oncotherm group and leads the strategic innovation of the company. He is associate professor having his Ph.D. in the highly specialized field of quality assurance of modern medical devices. His research activity covers the wide field of Oncotherm research and applications. The number of his publications is over 40 including books and articles and he has more than 10 patents.
Hyperthermia in oncology is a tool of destroying the malignant cells on the thermal way. The action could be a direct thermal toxicity for cells and/or boost other therapies to eliminate cancer cells. The definite aim of curative hyperthermia is to be selective in the malignant cells. The tumor has a complex structure, contains various compartments from where the therapy have to select the targets. Furthermore, the malignancy is systemic; metastases appear. The task is to extend the local thermal effect to systemic. Our objective is to show how the selection and systematization could be managed by hyperthermia from bench to bedside; targeting the abscopal effects induced by local treatment.
The method, which we had introduced is a modulated radio-frequency (RF) electro-hyperthermia treatment (mEHT, trade name: endothermic). This technology is impedance controlled capacitive coupling with amplitude modulated 13.56 MHz carrier frequency by the time-fractal pattern . mEHT selectively targets the transmembrane protein clusters of malignant cells . The group of these transmembrane proteins is naturally built-up nanoparticles in the membranes of malignant cells by definitely expressed lipid rafts .The nano-heating of rafts is the thermal effect without direct heating of the mass of the tumor . It is measured that the rafts’ temperature is at least 3°C higher than the lipids around it .
mEHT induced massive apoptotic cell death in the treated tumors by the caspase-independent subroutine in HT29 colorectal adenocarcinoma xenografts . This programmed cell death produces damage associated molecular pattern which is a prerequisite of the immunogenic cell death . The abscopal effect was measured in the murine model in conjunction with an intratumoral dendritic cell (DC) injection, . The mEHT plus DC administration significantly inhibits the tumor growth, while even no re-challenging of the tumor was possible, . In this case, the abscopal effect works like the vaccination. The mEHT method is successfully applied in many clinics , having some running and finished clinical studies for gliomas , ,for hepatocellular carcinoma , for colorectal liver metastasis , for lung  and for numerous others .
mEHT induces tumor cell apoptosis and creates favorable tumor microenvironment for the tumor-specific immunological chain reaction. It is directly applied curatively in numerous hospitals and clinics.
 Szasz O. Open J Biophysics, 3:245-252 (2013)
 Szasz O et.al J ClinOncol 33, (suppl; abstr e22176) (2015)
 Oncology-Centres-network; Sci Reports 3 : 1449; (2013)
 Szasz A, Thermal Med 29:1-23, (2013)
 Andocs G. et.al. Biol and Med, 7(4):1-9;(2015)
 Meggyeshazi N. et.al. StrahlentherOnkol, 190:815-822; (2014)
 Andocs G. et.al. Cell Stress and Chaperones, 20:37-46; (2015)
 Qin W et.al. Oncol Rep 32:2373-2379; (2014)
 Tsang Y-W et al. BMC Cancer 15:708; (2015)
 Szasz A et.al. Oncothermia, Springer, (2010)
 Wismeth C, et al. J Neurooncol 98(3):395–405 (2010)
Sahinbas H, et al. Deutsche ZeitschriftOnkologie 39:154–160 (2007)
 Gadaleta-Caldarola G, et al. Oncol Lett, 2014 Oct,8(4):1783-1787 (2014)
 Hager ED, et al. Anticancer Res 19(4C):3403–3408 (1999)
Szasz A, Korean J ThoracCardiovascSurg 47:77-93 (2014)